資訊中心NEWS CENTER
在發(fā)展中求生存，不斷完善，以良好信譽(yù)和科學(xué)的管理促進(jìn)企業(yè)迅速發(fā)展INTRODUCTION
One challenge facing peptide synthesis is the -lactam formation of arginine （Figure 1）. The formation of -lactam occurs when the internal nitrogen of the guanidine attacks the activated ester, irreversibly forming the lactam ring. This reaction is competitive with peptide-bond formation, greatly reducing the coupling efficiency of arginine.
Figure 1: γ-Lactam Formation
The goal of this study was to determine what effect microwave irradiation has on -lactam formation and how to optimize the microwave synthesis of arginine-containing peptides. As a test substrate, we selected the 1992 ABRF study peptide sequence. This sequence is known to suffer from Arg deletion due to -lactam formation.
更多詳情，請培安公司：
：北京： 上海： 成都： 廣州：
: sales@pynnco.com ：www.pynnco.com
SCROLL
聯(lián)系人：高
座機(jī)：010-65528800
地址：北京市朝陽區(qū)吉慶里14號佳匯國際A202室
快速導(dǎo)航
產(chǎn)品系列
產(chǎn)品推薦
Copyright©2025 培安有限公司 版權(quán)所有 All Rights Reserved 備案號：京ICP備17026558號-1 總訪問量：426627
技術(shù)支持：化工儀器網(wǎng) 管理登錄 sitemap.xml
手機(jī)：010-65528800